Veronese_et_al_2019_4.docx (70.64 kB)
Prospective associations of cardiovascular disease with physical performance and disability: a longitudinal cohort study in the Osteoarthritis Initiative
journal contribution
posted on 2023-08-30, 16:38 authored by Nicola Veronese, Brendon Stubbs, Sarah E. Jackson, Ai Koyanagi, Vania Noventa, Francesco Bolzetta, Alberto Cester, Pinar Soysal, Stefania Maggi, Guillermo F. López-Sánchez, Mike Loosemore, Jacopo Demurtas, Lee SmithBackground: Literature regarding cardiovascular disease (CVD) and incident physical performance limitations/disability in older people is equivocal.
Aims: We aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations/disability in a large population-based sample.
Methods: It was an eight-year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed)/disability score were analyzed using generalized linear models with repeated measures.
Results: The analyzed sample comprised 4,796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8-year follow-up period than those without CVD (p=0.006).
Conclusions: In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8-year follow-up period than those without CVD. However, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.
History
Refereed
- Yes
Volume
132Page range
73-78Publication title
Wiener Klinische Wochenschrift: The Central European Journal of MedicineISSN
1613-7671External DOI
Publisher
SpringerFile version
- Accepted version
Language
- eng
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Legacy posted date
2019-10-08Legacy creation date
2019-10-08Legacy Faculty/School/Department
Faculty of Science & EngineeringUsage metrics
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