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Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing

journal contribution
posted on 2023-08-30, 19:51 authored by Nicola Veronese, Marianna Noale, Alberto Cella, Carlo Custodero, Lee Smith, Marina Barbagelata, Stefania Maggi, Mario Barbagallo, Carlo Sabba, Luigi Ferrucci, Alberto Pilotto
Purpose- Frailty has been found to be associated with poor quality of life (QoL) in older people, but data available are limited to cross-sectional studies. We therefore aimed to assess the association between multidimensional frailty, determined by Multidimensional Prognostic Index (MPI), with mortality and good QoL expectancy (GQoLE) in a large representative sample of older adults, over 10 years of follow-up. Methods- In the English Longitudinal Study of Ageing, using the data from 2004–2005 and 2014–2015, MPI was calculated using a weighted score of domains of comprehensive geriatric assessment, i.e., number of difficulties in activities of daily living (ADL) and instrumental ADL, depressive symptoms, number of medical conditions, body mass index, physical activity level, and social aspects. Mortality was assessed using administrative data, GQoLE indicators were used for longitudinal changes in QoL. Results- 6244 Participants (mean age 71.8 years, 44.5% males) were followed up for 10 years. After adjusting for potential confounders, compared to people in the MPI low-risk group, people in the moderate (hazard ratio, HR = 4.27; 95% confidence interval, CI 3.55–5.14) and severe-risk group (HR = 10.3; 95% CI 7.88–13.5) experienced a significantly higher mortality rate. During the follow-up period, people in the moderate and severe-risk groups reported lower GQoLE values than their counterparts, independently from age and gender. Conclusions- Multidimensional frailty was associated with a higher risk of mortality and significantly lower GQoLE, suggesting that the multifactorial nature of frailty is associated not only with mortality, but also poor QoL.

History

Refereed

  • Yes

Volume

0

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0

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0

Publication title

Quality of Life Research

ISSN

1573-2649

Publisher

Springer

File version

  • Accepted version

Language

  • eng

Legacy posted date

2022-04-26

Legacy creation date

2022-04-26

Legacy Faculty/School/Department

Faculty of Science & Engineering

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