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Effect of non-cross-linked calcium on characteristics, swelling behaviour, drug release and mucoadhesiveness of calcium alginate beads

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posted on 2023-08-30, 14:18 authored by Adnan Al Dalaty, Ayman Karam, Mohammad Najlah, Raid G. Alany, Mouhamad Khoder
In this study, ibuprofen-loaded calcium alginate beads (CABs) with varying amounts of non-cross-linked calcium (NCL-Ca) were prepared using different washing methods. The influence of NCL-Ca on beads properties was investigated. Increasing the number or duration of washes led to significant decreases in the amount of NCL-Ca whereas the impact of the volume of washes was not significant. Approximately 70% of the initial amount of Ca(2+) was NCL-Ca which was removable by washing while only 30% was cross-linked (CL-Ca). Ca(2+) release from the CABs was bimodal; NCL-Ca was burst-released followed by a slower release of CL-Ca. Washing methods and the amount of NCL-Ca had significant influences on the encapsulation efficiency, beads weight, beads swelling, drug release profile and the mucoadhesiveness of CABs. This study highlighted the importance of washing methods and the amount of NCL-Ca to establish CABs properties and understand their behaviour in the simulated intestinal fluids (SIFs).

History

Refereed

  • Yes

Volume

140

Page range

163-70

Publication title

Carbohydrate Polymers

ISSN

1879-1344

Publisher

Elsevier

File version

  • Accepted version

Language

  • eng

Legacy posted date

2016-06-29

Legacy creation date

2016-06-13

Legacy Faculty/School/Department

ARCHIVED Faculty of Medical Science (until September 2018)

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