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Dark Classics in Chemical Neuroscience: An Evidence-Based Systematic Review of Belladonna

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journal contribution
posted on 2023-08-30, 17:28 authored by Vimal K. Maurya, Swatantra Kumar, Russell Kabir, Gaurav Shrivastava, Karuna Shanker, Debadatta Nayak, Anil Khurana, Raj K. Manchanda, Srinivasulu Gadugu, Sujita K. Kar, Anoop K. Verma, Shailendra K. Saxena
Belladonna has diverse pharmacotherapeutic properties with shadowy history of beauty, life, and death. Alkaloids present in belladonna have anti-inflammatory, anticholinergic, antispasmodic, mydriatic, analgesic, anticonvulsant, antimicrobial, which makes it widely applicable for the treatment of various diseases. However, due to its associated toxicity, the medicinal use of belladonna is debatable. Therefore, an evidence-based systematic review was planned to elucidate the pharmacotherapeutic potential of belladonna. A comprehensive literature search was performed in PubMed, MEDLINE, Cochrane database, Embase, and ClinicalTrial.gov using keywords ‘belladonna’ or ‘belladonna and clinical trials’ or ‘safety and efficacy of belladonna’. Articles published from 1965 to 2020, showing the efficacy of bel-ladonna in diverse clinical conditions were included. The quality of evidence was generated using GRADE approach and twenty studies involving 2302 patients were included for the systematic review. Our analyses suggest that belladonna treatment appears to be safe and effective in various disease conditions including acute encephalitis syndrome, urethral stent pain, myocardial ischemia injury, airway obstructions during sleep in infants, climacteric complaints, irritable bowel syndrome, and throbbing headache. However, the better understanding of the dosage, toxicity of tropane alkaloids of belladonna could make it efficient remedy for treating diverse medical conditions.

History

Refereed

  • Yes

Volume

11

Issue number

23

Page range

3937-3954

Publication title

ACS Chemical Neuroscience

ISSN

1948-7193

Publisher

American Chemical Society

File version

  • Accepted version

Language

  • eng

Legacy posted date

2020-07-20

Legacy creation date

2020-07-20

Legacy Faculty/School/Department

Faculty of Health, Education, Medicine & Social Care

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