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Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature
journal contribution
posted on 2023-09-01, 14:39 authored by Nicola Veronese, Jacopo Demurtas, Lin Yang, Roberto Tonelli, Mario Barbagallo, Pierluigi Lopalco, Erik Lagolio, Stefano Celotto, Damiano Pizzol, Liye Zou, Mark A. Tully, Petre Ilie, Mike Trorr, Guillermo F. López-Sánchez, Lee SmithThe aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition.
History
Refereed
- Yes
Volume
7Page range
170Publication title
Frontiers in MedicineISSN
2296-858XExternal DOI
Publisher
Frontiers MediaFile version
- Accepted version
Language
- eng
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Legacy posted date
2020-04-15Legacy creation date
2020-04-15Legacy Faculty/School/Department
COVID-19 Research CollectionUsage metrics
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