Anglia Ruskin University
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The role of YKL-40 in the pathogenesis of autoimmune diseases: a comprehensive review

journal contribution
posted on 2023-08-30, 19:58 authored by Kalthoum Tizaoui, Jae Won Yang, Keum Hwa Lee, Ji Hong Kim, Minseok Kim, Sojung Yoon, Yeonwoo Jung, Joon Beom Park, Kitae An, Hyeok Choi, Donggyu Song, Hyun Taek Jung, Seongmin Ahn, Taeho Yuh, Hee Min Choi, Jae Ha Ahn, Younjoung Kim, Sanghyun Jee, Hyeongsun Lee, Soohwa Jin, Jun-Gu Kang, Bohyun Koo, Joo Yeop Lee, Kyoung Min, Wonseok Yoo, Hyeong Jun Rhyu, Yeonjung Yoon, Min Ho Lee, Sung Eun Kim, Jimin Hwang, Ai Koyanagi, Louis Jacob, Seoyeon Park, Jae Il Shin, Lee Smith
YKL-40, a chitinase-3-like protein 1 (CHI3L1) or human cartilage glycoprotein 39 (HC gp-39), is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells and vascular smooth muscle cells. Its biological function is not well elucidated, but it is speculated to have some connection with inflammatory reactions and autoimmune diseases. Although having important biological roles in autoimmunity, there were only attempts to elucidate relationships of YKL-40 with a single or couple of diseases in the literature. Therefore, in order to analyze the relationship between YKL-40 and the overall diseases, we reviewed 51 articles that discussed the association of YKL-40 with rheumatoid arthritis, psoriasis, systemic lupus erythematosus, Behçet disease and inflammatory bowel disease. Several studies showed that YKL-40 could be assumed as a marker for disease diagnosis, prognosis, disease activity and severity. It is also shown to be involved in response to disease treatment. However, other studies showed controversial results particularly in the case of Behçet disease activity. Therefore, further studies are needed to elucidate the exact role of YKL-40 in autoimmunity and to investigate its potential in therapeutics.



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International Journal of Biological Sciences




Ivyspring International Publisher

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  • Accepted version


  • eng

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Faculty of Science & Engineering

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