Najlah_2015.pdf (709.01 kB)
The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
journal contributionposted on 2023-07-26, 13:59 authored by Patricia E. Tawari, Zhipeng Wang, Mohammad Najlah, Chi Wai Tsang, Vinodh Kannappan, Peng Liu, Christopher McConville, Bin He, Angel L. Armesilla, Weiguang Wang
The anticancer activity of disulfiram (DS) is copper(II) (Cu)-depen-dent. This study investigated the anticancer mechanisms of DS/Cuusingin vitrocytotoxicity and metabolic kinetic analysis. Our studyindicates that DS/Cu targets cancer cells by the combination oftwo types of actions: (1) instant killing executed by DS/Cu reactiongenerated reactive oxygen species; (2) delayed cytotoxicity intro-duced by the end product, DDC-Cu. Nanoencapsulation of DSmight shed light on repositioning of DS into cancer treatment.
Publication titleToxicology Research
PublisherRoyal Society of Chemistry
- Published version