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The contribution of zinc to platelet behaviour during haemostasis and thrombosis
journal contribution
posted on 2023-09-01, 13:55 authored by Nicholas Pugh, Kirk A. TaylorPlatelets are the primary cellular determinants of haemostasis and pathological thrombus formation leading to myocardial infarction and stroke. Following vascular injury or atherosclerotic plaque rupture, platelets are recruited to sites of damage and undergo activation induced by a variety of soluble and/or insoluble agonists. Platelet activation is a multi-step process culminating in the formation of thrombi, which contribute to the haemostatic process. Zinc (Zn2+) is acknowledged as an important signalling molecule in a diverse range of cellular systems, however there is limited understanding of the influence of Zn2+ on platelet behaviour during thrombus formation. This review evaluates the contributions of exogenous and intracellular Zn2+ to platelet function and assesses the potential pathophysiological implications of Zn2+ signalling. We also provide a speculative assessment of the mechanisms by which platelets could respond to changes in extracellular and intracellular Zn2+ concentration.
History
Refereed
- Yes
Volume
8Page range
144-155Publication title
MetallomicsISSN
1756-591XExternal DOI
Publisher
Royal Society of ChemistryFile version
- Accepted version
Language
- eng
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Legacy posted date
2016-02-02Legacy creation date
2020-02-20Legacy Faculty/School/Department
ARCHIVED Faculty of Science & Technology (until September 2018)Usage metrics
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