Anglia Ruskin University
1-s2.0-S0167494323002388-main.pdf (1.05 MB)
Download file

Sarcopenia using muscle mass prediction model and cognitive impairment: a longitudinal analysis from the English Longitudinal Study on Ageing

Download (1.05 MB)
journal contribution
posted on 2023-09-05, 15:09 authored by Laura Maniscalco, Nicola Veronese, Francesco Ragusa, Laura Vernuccico, Ligia Dominguez, Lee Smith, Domenica Matranga, Mario Barbagallo


Literature on the association between sarcopenia and cognitive impairment is largely unclear and mainly limited to non-European populations. Therefore, the aim of this study is to explore if the presence of sarcopenia at the baseline could increase the risk of cognitive impairment in a large cohort of older people participating to the English Longitudinal Study of Ageing (ELSA), over ten years of follow-up.


Sarcopenia was diagnosed as having low handgrip strength and low skeletal muscle mass index at the baseline, using a muscle mass prediction model; cognitive function was evaluated in the ELSA through several tests. The results are reported in the whole sample adjusted for potential baseline confounders and after matching sarcopenic and non-sarcopenic participants with a propensity score.


2738 people (mean age: 68.7 years, 54.4% males) were included. During the ten years of follow-up, sarcopenia was associated with significantly lower scores in memory (p < 0.001), verbal fluency (p < 0.001), immediate word recall (p <0.001), delayed word recall (p = 0.018), and in recall summary score (p < 0.001). After adjusting for eight potential confounders, the presence of sarcopenia was significantly associated with poor verbal fluency (odds ratio, OR= 1.417, 95% confidence intervals, CI= 1.181–1.700) and in propensity-score matched analyses (OR=1.272, 95%CI= 1.071- 1.511).

Conclusions and implications

Sarcopenia was found to be associated with a significantly higher incidence of poor cognitive status in a large population of elderly people followed up for 10 years, suggesting it may be an important potential risk factor for dementia.



  • Yes



Publication title

Archives of Gerontology and Geriatrics





File version

  • Published version

Item sub-type


Affiliated with

  • School of Humanities and Social Sciences Outputs

Usage metrics

    ARU Outputs