Anglia Ruskin Research Online (ARRO)
1-s2.0-S0165032723001167-main.pdf (242.88 kB)

Reduced grip strength potentially indicates depression: Investigating multicontinental databases

Download (242.88 kB)
journal contribution
posted on 2024-03-06, 10:00 authored by Jae Won Oh, Sun Mi Kim, Deokjong Lee, Dong Keon Yon, Seung Won Lee, Lee Smith, Karel Kostev, Ai Koyanagi, Mark Solmi, Andre Carvalho, Jae Il Shin, Nak-Hoon Son, San Lee

Background: Multi-national studies in the association between handgrip strength and depression in middle and older aged adults are limited. Hence, Brazil, China, Europe, Korea, United Kingdom (UK) and United States (US) datasets were utilized to investigate this association. Methods: A cross-sectional study was conducted with 51,285 participants aged >45 years. Handgrip strength scores were divided into quartiles, groups 1 (highest) to 4 (lowest) in each database, and depression measures converted to binary scores. Results: Males in China and UK reported higher adjusted odds ratios (aORs) of depression for groups 2, 3, and 4 than for group 1. Brazil, US, and Korea reported greater aORs in groups 3 and 4 whereas Europe demonstrated increased aORs for group 4 only. Among females, China, Brazil, US, and Korea showed high aORs across all groups, while UK and Europe reported increased aORs for group 4 only. Highest ORs were reported from Korea in group 4 for males (aOR: 3·09; 95 % CI: 2·15–4·43; p < 0·001) and females (aOR: 3·74; 95 % CI: 2·78–5·03; p < 0·001). When removing the regional factor, aORs were higher in lower groups, with the highest reported from group 4 for males (aOR: 2·32; 95 % CI: 2·09–2·58; p < 0·001) and females (aOR: 2·11; 95 % CI: 1·95–2·29; p < 0·001). Limitations: Being a cross-sectional study, the results were not able to establish the causal direction between handgrip strength and depression. Conclusion: Lower handgrip strength was associated with an increased likelihood of depression. Early assessment of handgrip strength may identify populations at-risk for depression among middle and older aged adults.



  • Yes



Page range


Publication title

Journal of Affective Disorders





File version

  • Published version


  • eng

Item sub-type


Affiliated with

  • School of Psychology and Sport Science Outputs