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Polo-like Kinase 1 Inhibition in KRAS-Mutated Metastatic Colorectal Cancer

Version 2 2024-06-25, 14:01
Version 1 2024-06-24, 10:48
journal contribution
posted on 2024-06-25, 14:01 authored by Justin Stebbing, Andrea J Bullock
Summary: Inhibition of Polo-like kinase 1 (Plk1) is a promising new target and therapeutic strategy in metastatic colorectal cancer, especially those with KRAS mutations. New data support further development of onvansertib, and highlights the role of circulating tumor DNA in phase I clinical trials. See related article by Ahn et al., p. 2039

History

Refereed

  • Yes

Volume

30

Issue number

10

Page range

2005-2007

Publication title

Clinical Cancer Research

ISSN

1078-0432

Publisher

American Association for Cancer Research (AACR)

Location

United States

File version

  • Accepted version

Language

  • eng

Item sub-type

Journal Article

Media of output

Print

Affiliated with

  • School of Life Sciences Outputs