Anglia Ruskin Research Online (ARRO)

File(s) under embargo

Physical Activity and Exercise for the Prevention and Management of Mild Cognitive Impairment and Dementia: A Collaborative International Guideline

journal contribution
posted on 2023-09-13, 14:54 authored by Nicola Veronese, Pinar Soysal, Jacopo Demurtas, Marco Solmi, Olivier Bruyere, Nikos Christodoulou, Rodrigo Ramalho, Paolo Fusar-Poli, Andreas Lappas, Daniel Pinto, Kristian Frederiksen, Grazia Corbi, Olga Karpenko, Jean Georges, Joao Duraes, Mathias Schlogl, Ozlem Yilmaz, Cornel Sieber, Susan Shenkin, Lee Smith, Jean-Yves Reginster, Stefania Maggi, Federica Limongi, Joan Ars, Mario Barbagallo, Antonio Cherubini, Terry Quinn

Background: Physical activity and exercise have been suggested as effective interventions for the prevention and management of mild cognitive impairment (MCI) and dementia, but there are no international guidelines.

Objectives: To create a set of evidence- and expert consensus-based prevention and management recommendations regarding physical activity (any bodily movement produced by skeletal muscles that results in energy expenditure) and exercise (a subset of physical activity that is planned, structured, repetitive), applicable to a range of individuals from healthy older adults to those with MCI/dementia. 

Methods: Guideline content was developed with input from several scientific and lay representatives’ societies. A systematic search across multidisciplinary databases was carried out until October 2021. Recommendations for prevention and management were developed according to the GRADE and complemented by consensus statements from the expert panels.

Recommendations: Physical activity may be considered for the primary prevention of dementia. In people with MCI there is continued uncertainty about the role of physical activity in slowing the conversion to dementia. Mind-body interventions have the greatest supporting evidence. In people with moderate dementia, exercise may be used for maintaining disability and cognition. All these recommendations were based on a very low/low certainty of evidence.

Conclusions:  Although the scientific evidence on the beneficial role of physical activity and exercise in preserving cognitive functions in subjects with normal cognition, MCI or dementia is inconclusive, this panel, composed of scientific societies and other stakeholders, recommends their implementation based on their beneficial effects on almost all facets of health. 



  • Yes

Publication title

European Geriatric Medicine





File version

  • Accepted version

Item sub-type


Affiliated with

  • School of Education and Social Care Outputs

Usage metrics

    ARU Outputs



    Ref. manager