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Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections

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journal contribution
posted on 2024-01-05, 14:35 authored by Yue He, Hongtao Rao, JingJing Wang, Ying Wu, Caiqin Han, Changchun Yan, Hunter Temple, Le Zhang, Wei Chen, Ying Liu

The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2 + QDs based on the combination of rare earth upconversion (UCNPs) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO2 + QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted in the visible wavelength, specifically identified and highly sensitive. Under the excitation of 980 nm near-infrared light, the UCNPs and QDs in the composite produced the maximum efficiency of energy transfer through fluorescence resonance, and the multi-emission light of UCNPs synergistically excited the re-emission of QDs, and the energy transfer efficiency is 70.6%. By changing the doping ratio of QDs halogen elements in UCNP@SiO2 + QDs, it is possible to modulate the precise luminescence of UCNP@SiO2 + QDs in the entire wavelength range of visible light at different positions. The novel fluorescent probe is obtained using UCNP@SiO2 + QDs and Black Hole Quencher-1 (BHQ1) quenching groups linked to the two respective sides of MB, selecting as the target of detection the myeloma cancer biomarker miRNA-155, a difficult diagnostic and complex developmental type, and have achieved specific recognition and low concentration of miRNA-155 and a detection limit of 73.5 pM. This fluorescent probe design can provide new ideas for the early diagnosis and treatment of cancer, tumors, and cardiovascular diseases. Graphical Abstract

History

Refereed

  • Yes

Volume

14

Number of pages

19

Publication title

Cancer Nanotechnology

ISSN

1868-6958

Publisher

Springer Science and Business Media LLC

File version

  • Published version

Language

  • eng

Item sub-type

Article, Journal

Affiliated with

  • Medical Technologies Research Centre (MTRC) Outputs