Veronese_et_al_2021.pdf (790.65 kB)
Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: a Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
journal contribution
posted on 2023-07-26, 15:35 authored by Nicola Veronese, Ligia Dominguez, Damiano Pizzol, Jacopo Demurtas, Lee Smith, Mario BarbagalloThere is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes, compared with a placebo. Several databases were searched investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or conditions at high risk of diabetes. Data were reported as standardized mean differences (SMDs) with their 95% confidence intervals (CIs) using follow-up data of glucose and insulin-sensitivity parameters. Compared with placebo, Mg supplementation reduced fasting plasma glucose in people with diabetes. In people at high risk of diabetes, Mg supplementation significantly improved plasma glucose per se, and after a 2 h oral glucose tolerance test. Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. In conclusion, Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes. Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes.
History
Refereed
- Yes
Volume
13Issue number
11Page range
4074Publication title
NutrientsISSN
2072-6643External DOI
Publisher
MDPIFile version
- Published version
Language
- eng