Bloor_et_al_2022.pdf (1.02 MB)
Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota
journal contribution
posted on 2023-07-26, 15:51 authored by Sarah R. Bloor, Rudolph Schutte, Anthony R. HobsonIron deficiency anaemia (IDA) is a worldwide healthcare problem affecting approximately 25% of the global population. The most common IDA treatment is oral iron supplementation, which has been associated with gastrointestinal (GI) side effects such as constipation and bloating. These can result in treatment non-adherence and the persistence of IDA. Intravenous iron does not cause GI side effects, which may be due to the lack of exposure to the intestinal lumen. Luminal iron can cause changes to the gut microbiota, aiding the promotion of pathogenic species and decreasing beneficial protective species. Iron is vital for methanogenic archaea, which rely on iron for growth and metabolism. Increased intestinal methane has been associated with slowing of intestinal transit, constipation, and bloating. Here we explore the literature to understand a potential link between iron and methanogenesis as a novel way to understand the mechanism of oral iron supplementation induced GI side effects.
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Refereed
- Yes
Volume
12Issue number
2Page range
491-502Publication title
Microbiology ResearchISSN
2036-7481External DOI
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MDPIFile version
- Published version
Language
- eng
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2022-05-16Legacy creation date
2022-05-16Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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