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Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: Concept and biomedical applications

journal contribution
posted on 2024-05-16, 10:43 authored by Youngeun Choi, Gavin Metcalf, Mazen Haj Sleiman, Douglas Vair-Turnbull, Sylvain Ladame

Sensing technologies based on Peptide Nucleic Acids (PNAs) and oligonucleotide-templated chemistry are perfectly suited for biomedical applications (e.g., diagnosis, prognosis and stratification of diseases) and could compete well with more traditional amplification technologies using expensive dual-labelled oligonucleotide probes. PNAs can be easily synthesised and functionalised, are more stable and are more responsive to point-mutations than their DNA counterpart. For these reasons, fluorogenic PNAs represent an interesting alternative to DNA-based molecular beacons for sensing applications in a cell-free environment, where cellular uptake is not required.

History

Refereed

  • Yes

Volume

22

Issue number

16

Page range

4395-4398

Publication title

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

Publisher

Elsevier BV

Language

  • eng

Affiliated with

  • School of Life Sciences Outputs