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Nutrition and Frailty: Opportunities for Prevention and Treatment

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posted on 2023-07-26, 15:27 authored by Mary Ni Lochlainn, Natalie J. Cox, Thomas Wilson, Richard P. G. Hayhoe, Sheena E. Ramsay, Antoneta Granic, Masoud Isanejad, Helen C. Roberts, Daisy Wilson, Carly Welch, Christopher Hurst, Janice L. Atkins, Nuno Mendonça, Katy Horner, Esme R. Tuttiett, Yvie Morgan, Phil Heslop, Elizabeth A. Williams, Claire J. Steves, Carolyn Greig, John Draper, Clare A. Corish, Ailsa A. Welch, Miles D. Witham, Avan A. Sayer, Sian Robinson
Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is considered a key contributor to its pathophysiology. As nutrition is a modifiable risk factor for frailty, strategies to prevent and treat frailty should consider dietary change. Observational evidence linking nutrition with frailty appears most robust for dietary quality: for example, dietary patterns such as the Mediterranean diet appear to be protective. In addition, research on specific foods, such as a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods are consistent, with healthier profiles linked to lower frailty risk. Few dietary intervention studies have been conducted to date, although a growing number of trials that combine supplementation with exercise training suggest a multi-domain approach may be more effective. This review is based on an interdisciplinary workshop, held in November 2020, and synthesises current understanding of dietary influences on frailty, focusing on opportunities for prevention and treatment. Longer term prospective studies and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression and how dietary change can be used to prevent and/or treat frailty in the future.

History

Refereed

  • Yes

Volume

13

Issue number

7

Page range

2349

Publication title

Nutrients

ISSN

2072-6643

Publisher

MDPI

File version

  • Published version

Language

  • eng

Legacy posted date

2021-07-22

Legacy creation date

2021-07-22

Legacy Faculty/School/Department

Faculty of Health, Education, Medicine & Social Care

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