Warburton_et_al_2016.pdf (427.85 kB)
Download fileMosaic tetracycline resistance genes encoding ribosomal protection proteins
journal contribution
posted on 2023-07-26, 13:58 authored by Philip J. Warburton, Nina Amodeo, Adam P. RobertsFirst reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria.
History
Refereed
- Yes
Volume
71Issue number
12Page range
3333-3339Publication title
Journal of Antimicrobial ChemotherapyISSN
1460-2091External DOI
Publisher
Oxford University PressFile version
- Published version
Language
- eng