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Hypomagnesemia is associated with excessive daytime sleepiness, but not insomnia, in older adults

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posted on 2024-01-16, 13:18 authored by Muhammed Tunc, Pinar Soysal, Ozge Pasin, Lee Smith, Masoud Rahmati, Veliye Yigitalp, Sevnaz Sahin, Moustapha Drame
The aim of this study was to investigate associations between serum magnesium levels with insomnia and excessive daytime sleepiness (EDS) in older adults. A total of 938 older outpatients were included in the study. Hypomagnesemia was defined as serum magnesium concentration below <1.6 mg/dL. Patients were divided into two groups: hypomagnesemia and normomagnesia (1.6–2.6 mg/dL). The Epworth Sleepiness Scale was implemented and scores of ≥11 points were categorized as EDS. The Insomnia Severity Index was implemented and scores of ≥8 indicated insomnia. The mean age was 81.1 ± 7.6 years. While the presence of EDS, hypertension, diabetes mellitus, and coronary artery disease were more common in the hypomagnesemia group than the normomagnesia group, Parkinson’s disease was less common (p < 0.05). Hemoglobin and HDL cholesterol were lower, whereas HbA1c, triglyceride, and number of drugs used were higher in the hypomagnesemia group compared to the normomagnesia group (p < 0.05). In both univariate analysis and multivariate analysis adjusted for gender, age and all confounders, there were significant associations between hypomagnesemia and EDS [odds ratio (OR):1.7; 95% confidence interval (CI): 1.6–2.6, and OR: 1.9; 95%CI: 1.2–3.3, respectively (p < 0.05)]. There was no significant relationship between hypomagnesemia and insomnia (p > 0.05). The present study identified an association between hypomagnesemia and EDS in older adults. Therefore, it may be prudent to consider hypomagnesemia when evaluating older adults with EDS and vice versa.

History

Refereed

  • Yes

Volume

15

Issue number

11

Publication title

Nutrients

ISSN

2072-6643

Publisher

MDPI AG

Location

Switzerland

File version

  • Published version

Language

  • eng

Item sub-type

Journal Article

Media of output

Electronic

Affiliated with

  • School of Psychology and Sport Science Outputs