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Fronto-striatal circuits in response-inhibition: Relevance to addiction

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journal contribution
posted on 2023-07-26, 13:45 authored by Sharon Morein-Zamir, Trevor W. Robbins
Disruptions to inhibitory control are believed to contribute to multiple aspects of drug abuse, from preexisting vulnerability in at-risk individuals, through escalation to dependence, to promotion of relapse in chronic users. Paradigms investigating the suppression of actions have been investigated in animal and human research on drug addiction. Rodent research has focused largely on impulsive behaviors, often gauged by premature responding, as a viable model highlighting the relevant role of dopamine and other neurotransmitters primarily in the striatum. Human research on action inhibition in stimulant dependence has highlighted impaired performance and largely prefrontal cortical abnormalities as part of a broader pattern of cognitive abnormalities. Animal and human research implicate inhibitory difficulties mediated by fronto-striatal circuitry both preceding and as a result of excessive stimulus use. In this regard, response-inhibition has proven a useful cognitive function to gauge the integrity of fronto-striatal systems and their role in contributing to impulsive and compulsive features of drug dependence. This article is part of a Special Issue entitled SI:Addiction circuits.

History

Refereed

  • Yes

Volume

1628

Issue number

A

Page range

117-129

Publication title

Brain Research

ISSN

1872-6240

Publisher

Elsevier

File version

  • Published version

Language

  • eng

Legacy posted date

2016-04-07

Legacy creation date

2019-05-16

Legacy Faculty/School/Department

ARCHIVED Faculty of Science & Technology (until September 2018)

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