Anglia Ruskin Research Online (ARRO)
Browse
- No file added yet -

Extended endocrine therapy in early breast cancer: how long and who for?

Download (651.52 kB)
journal contribution
posted on 2023-08-30, 17:10 authored by John R. Benson, Ismail Jatoi
Endocrine therapy for early stage breast cancer is currently in a state of flux with much uncertainty about choice of agents and duration of therapy. The standard treatment span of 5 years usually incorporates an aromatase inhibitor in the majority of postmenopausal patients. Hormonal therapy has a cytostatic action that provides a biological rationale for continuing treatment for more prolonged periods to reduce risk of late recurrence in estrogen receptor-positive disease. Several trials of extended endocrine therapy for periods varying from 7.5 to 10 years have shown mixed results for gains in disease-free survival. The challenge is to assimilate available data and apply clinical judgment to tailor therapies taking account of intrinsic risk of disease recurrence, patient preference, tolerability to date, and co-morbidities.

History

Refereed

  • Yes

Volume

16

Issue number

1

Page range

4327-4336

Publication title

Future Oncology

ISSN

1744-8301

Publisher

Future Medicine

File version

  • Accepted version

Language

  • eng

Legacy posted date

2020-04-24

Legacy creation date

2020-04-24

Legacy Faculty/School/Department

Faculty of Health, Education, Medicine & Social Care

Usage metrics

    ARU Outputs

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC