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Engineering innovative solutions to screen for prostate cancer

journal contribution
posted on 2024-05-16, 10:23 authored by Dana Al Sulaiman, Gavin AD Metcalf, Sylvain Ladame

The search for non-invasive tools for the diagnosis and management of cancer has long been a major goal of cancer research. Cost-effective technologies for blood-based, sensitive and specific detection of nucleic acid biomarkers could potentially transform the way cancer is diagnosed and treated. Circulating microRNAs in blood have recently emerged as clinically useful and minimally invasive predictive, diagnostic and prognostic biomarkers for prostate cancer. However, they are very challenging to detect accurately due to their low concentration and high sequence homology. Herein we highlight the main limitations of the current gold-standard technologies for microRNA detection (including complexity and cost) and discuss recent technological advances toward new blood tests suitable for widespread public screening.

History

Refereed

  • Yes

Volume

3

Issue number

1

Page range

016001-016001

Publication title

Convergent Science Physical Oncology

ISSN

2057-1739

Publisher

IOP Publishing

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