Anglia Ruskin Research Online (ARRO)
Browse

Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

Download (1.16 MB)
journal contribution
posted on 2023-08-30, 14:31 authored by Mouhamad Khoder, Hamdy Abdelkader, Amr ElShaer, Ayman Karam, Mohammad Najlah, Raid G. Alany
The aim of this study was to investigate the use of bovine serum albumin (BSA) as a solubility enhancer for indometacin (IND) as a model drug. IND-BSA solid dispersions were prepared by both spray drying and freeze drying techniques using IND:BSA solution (20:1 Molar Ratio (MR)) and IND:BSA suspension (100:1 MR). The solid state of IND in solid dispersions was characterised by SEM, DSC and XRD. The aqueous solubility of IND in the presence of increased amounts of BSA was evaluated. Additionally, IND dissolution and release profiles were evaluated. IND in solid dispersions with BSA showed significantly higher solubility in water than that of the physical mixture of both. Enhancement factors of 24,000 and 100,000 were obtained for the solid dispersion formulated in 20:1 MR and 100:1 MR, respectively. Dissolution studies in-vitro indicated a significant increase in the dissolution rate of IND from solid dispersions compared to that of the free drug, with almost 95% of the drug dissolved in the first 5 min. Furthermore, an immediate release of IND from BSA solid dispersions was shown. The potential use of albumin as solubility enhancer for poorly soluble drugs, particularly, for immediate release volume-limited dosage forms is reported.

History

Refereed

  • Yes

Volume

515

Issue number

1-2

Page range

740-748

Publication title

International Journal of Pharmaceutics

ISSN

1873-3476

Publisher

Elsevier

File version

  • Accepted version

Language

  • eng

Legacy posted date

2016-11-14

Legacy creation date

2016-11-13

Legacy Faculty/School/Department

ARCHIVED Faculty of Medical Science (until September 2018)

Usage metrics

    ARU Outputs

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC