Efficacy and safety of topical Streptococcus postbiotic emollient in adolescents and adults with mild-to-moderate atopic dermatitis: a randomized, double-blind, vehicle-controlled trial

<p dir="ltr">Atopic dermatitis (AD), a chronic inflammatory pruritic skin disorder, involves significant alternations in the skin microbiome compositions and reduction in filaggrin, a structural protein comprising epidermal barriers. Previous research conducted highlighted the beneficial role of <i>Streptococcus</i> in enhancing skin elasticity, moisture contents, and the expression of filaggrin. Building upon these findings, we designed a proof-of-concept trial to evaluate the efficacy of a topical <i>Streptococcus</i> postbiotic emollient, specifically Strain CX, in 100 participants with mild-to-moderate AD. Our assessment encompassed clinical effects, laboratory parameters, and safety observations over 24 weeks.</p>