Efficacy and safety of topical Streptococcus postbiotic emollient in adolescents and adults with mild-to-moderate atopic dermatitis: a randomized, double-blind, vehicle-controlled trial

Atopic dermatitis (AD), a chronic inflammatory pruritic skin disorder, involves significant alternations in the skin microbiome compositions and reduction in filaggrin, a structural protein comprising epidermal barriers. Previous research conducted highlighted the beneficial role of Streptococcus in enhancing skin elasticity, moisture contents, and the expression of filaggrin. Building upon these findings, we designed a proof-of-concept trial to evaluate the efficacy of a topical Streptococcus postbiotic emollient, specifically Strain CX, in 100 participants with mild-to-moderate AD. Our assessment encompassed clinical effects, laboratory parameters, and safety observations over 24 weeks.