<p>Stereotype is a pervasive and persistent human tendency that stems from a basic cognitive need to categorize, simplify, and process the complex world. This tendency is a precondition for social bias, prejudice, and discrimination. Amid the COVID-19 outbreak, the discrimination, exclusion, and even hostility caused by stereotypes have increasingly become an important social issue that concerns political and social stability. Therefore, the current issue focuses on a broad spectrum of research addressing four main themes: (1) the psychological processes involved in forming and internalizing social stereotypes, (2) the negative consequences of stereotypes, (3) the neurocognitive mechanisms underlying stereotypes, and (4) the interventions addressing the consequences of negative stereotypes in this era with changes and challenges. Specifically, the Research Topic consists of 13 papers by 54 scholars that target stereotypes among different social groups, including males and females, older people and young generation, minority races, people living with HIV/AIDS (PLWHA), people with mental health problems, juvenile transgressors, refugees, and Asian-Americans during COVID-19 outbreak. These studies are conducted in culturally diverse countries including Brazil, China, Germany, Hungary, and the USA, contributing to a more holistic picture of contemporary stereotypes. </p>