Dose-response association of handgrip strength and risk of depression: a longitudinal study of 115 601 older adults from 24 countries
journal contribution
posted on 2023-08-30, 20:20 authored by Ruben Lopez-Bueno, Joaquin Calatayud, Lars Louis Anderson, Jose Casana, Ai Koyanagi, Borja Del Pozo Cruz, Lee SmithBackground
Prior research has solely focused on the association between handgrip strength and risk of depression in single countries or general populations, but more knowledge is required from wider-spread cohorts and target populations.
Aims
This study aimed to investigate the association between handgrip strength and risk of depression using repeated measures in adults aged 50 years and over.
Method
Data on handgrip strength and risk of depression were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7, using a hand dynamometer (Smedley, S Dynamometer, TTM) and the EURO-D 12-item scale, respectively. Time-varying exposure and covariates were modelled using both Cox regression and restricted cubic splines.
Results
A total of 115 601 participants (mean age 64.3 years (s.d. = 9.9), 54.3% women) were followed-up for a median of 7.3 years (interquartile range: 3.9–11.8) and 792 459 person-years. During this period, 30 208 (26.1%) participants experienced a risk of depression. When modelled as a continuous variable, we observed an inverse significant association for each kg increase of handgrip strength and depression up to 40 kg in men and up to 27 kg in women.
Conclusions
Being physically strong may serve as a preventive factor for depression in older adults, but this is limited up to a maximum specific threshold for men and women.
History
Refereed
- Yes
Volume
222Issue number
3Page range
135-142Publication title
British Journal of PsychiatryISSN
1472-1465External DOI
Publisher
Cambridge University PressFile version
- Accepted version
Language
- eng