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Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?
journal contribution
posted on 2023-07-26, 14:34 authored by Marco Viceconti, Muhammad Qasim, Pinaki Bhattacharya, Xinshan LiPurpose of Review: This study reviews the available literature to compare the accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) and of subject-specific finite element models derived from quantitative computed tomography (QCT-SSFE) in predicting bone strength measured experimentally on cadaver bones, as well as their clinical accuracy both in terms of discrimination and prediction. Based on this information, some basic cost-effectiveness calculations are performed to explore the use of QCT-SSFE instead of DXA-aBMD in (a) clinical studies with femoral strength as endpoint, (b) predictor of the risk of hip fracture in low bone mass patients. Recent Findings: Recent improvements involving the use of smooth-boundary meshes, better anatomical referencing for proximal-only scans, multiple side-fall directions, and refined boundary conditions increase the predictive accuracy of QCT-SSFE. Summary: If these improvements are adopted, QCT-SSFE is always preferable over DXA-aBMD in clinical studies with femoral strength as the endpoint, while it is not yet cost-effective as a hip fracture risk predictor, although pathways that combine both QCT-SSFE and DXA-aBMD are promising.
History
Refereed
- Yes
Volume
16Issue number
3Page range
216-223Publication title
Current Osteoporosis ReportsISSN
1544-2241External DOI
Publisher
SpringerFile version
- Published version
Language
- eng
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Legacy posted date
2019-03-27Legacy creation date
2019-03-27Legacy Faculty/School/Department
ARCHIVED Faculty of Science & Technology (until September 2018)Usage metrics
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