Anglia Ruskin Research Online (ARRO)
Browse

File(s) not publicly available

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

journal contribution
posted on 2023-07-26, 15:16 authored by Hamdy Abdelkader, Raid G. Alany, Barbara K. Pierscionek
Objectives: The search for anticataract drugs has been continuing for decades; some treatments no longer exist but antioxidants are still of much interest. Key findings: The primary function of the human lens, along with the cornea, is to refract light so that it is correctly focused onto the retina for optimum image quality. With age, the human lens undergoes morphological, biochemical and physical changes leading to opacification. Age-related or senile cataract is one of the main causes of visual impairment in the elderly; given the lack of access to surgical treatment in many parts of the world, cataract remains a major cause of sight loss. Surgical treatment is the only means of treating cataract; this approach, however, has limitations and complications. Summary: This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.

History

Refereed

  • Yes

Volume

67

Issue number

4

Page range

537-550

Publication title

Journal of Pharmacy and Pharmacology

ISSN

2042-7158

Publisher

Oxford University Press

Language

  • other

Legacy posted date

2021-02-22

Legacy Faculty/School/Department

ARCHIVED Faculty of Health, Social Care & Education (until September 2018)

Usage metrics

    ARU Outputs

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC