File(s) not publicly available
A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization
journal contributionposted on 2023-07-26, 13:59 authored by Mohammad Najlah, Kanar Hidayat, Huner K. Omer, Enosh Mwesigwa, Waqar Ahmed, Kais G. AlObaidy, David A. Phoenix, Abdelbary M. A. Elhissi
In this study, a niosome nanodispersion was manufactured using high-pressure homogenization following the hydration of proniosomes. Using beclometasone dipropionate (BDP) as a model drug, the characteristics of the homogenized niosomes were compared with vesicles prepared via the conventional approach of probe-sonication. Particle size, zeta potential, and the drug entrapment efficiency were similar for both size reduction mechanisms. However, high-pressure homogenization was much more efficient than sonication in terms of homogenization output rate, avoidance of sample contamination, offering a greater potential for a large-scale manufacturing of noisome nanodispersions. For example, high-pressure homogenization was capable of producing small size niosomes (209 nm) using a short single-step of size reduction (6 min) as compared with the time-consuming process of sonication (237 nm in >18 min) and the BDP entrapment efficiency was 29.65% ± 4.04 and 36.4% ± 2.8. In addition, for homogenization, the output rate of the high-pressure homogenization was 10 ml/min compared with 0.83 ml/min using the sonication protocol. In conclusion, a facile, applicable, and highly efficient approach for preparing niosome nanodispersions has been established using proniosome technology and high-pressure homogenization.
Publication titleJournal of Liposome Research
PublisherTaylor & Francis