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Data Mining the Protein Data Bank to Identify and Characterise Chameleon Coil Sequences that Form Symmetric Homodimer β-Sheet Interfaces
conference contribution
posted on 2023-07-26, 15:16 authored by Johanna Laibe, Melanie Broutin, Aaron Caffrey, Barbara K. Pierscionek, Jean-Christophe NebelA protein’s environment may affect its secondary structure. In this study, the focus is on homodimers with symmetric β-sheet interfaces resulting from the conversion of coil sequences into β-strands. All homodimers in the Protein Data Bank relying on those chameleon sequences have been identified. Initial analysis based on sequential and structural features has revealed that many of those dimers display specific properties which could contribute to their detection. Such result is important since it could provide some insight on dimerisation and possibly aggregation mechanisms.
History
Page range
118-126ISSN
0302-9743External DOI
Publisher
SpringerISBN
978-3-319-56153-0Conference proceeding
Bioinformatics and Biomedical Engineering: 5th International Work-Conference, IWBBIO 2017, Granada, Spain, April 26–28, 2017, Proceedings, Part IIName of event
5th International Work-Conference (IWBBIO 2017)Location
Granada, SpainEvent start date
2017-04-26Event finish date
2017-04-28Editors
Ignacio Rojas, Francisco OrtuñoLanguage
- other